Description

CA ATRA-IO is a medicinal product containing all-trans retinoic acid (tretinoin) in the form of soft gelatin capsules. It belongs to the class of retinoids, which are natural or synthetic derivatives of vitamin A. Tretinoin is used in medical practice to regulate cell growth, differentiation, and maturation.

This medicine plays an important role in the treatment of certain serious hematological conditions and must be used only under strict medical supervision.

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🔹 Pharmacological Group

Retinoids
Vitamin A derivatives

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🔹 Active Ingredient

All-trans retinoic acid (tretinoin) — 10 mg per capsule

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🔹 Mechanism of Action

Tretinoin is an active form of vitamin A that affects gene expression regulating:

• cellular growth

• differentiation

• tissue regeneration

It:

• normalizes the cell life cycle;

• stimulates maturation of abnormal cells;

• reduces pathological proliferation.

These properties make it useful in treating disorders associated with abnormal cell development.

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🔹 Indications

Indications are determined by a physician and may include:

✔ Treatment of acute promyelocytic leukemia (APL) as part of combination oncology therapy protocols.

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🔹 Administration

• taken orally with water;

• dosage and treatment duration are determined individually by a physician;

• capsules must not be chewed or opened;

• therapy should be conducted under medical supervision.

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🔹 Contraindications

• hypersensitivity to retinoids or components of the medicine;

• severe liver disorders;

• pregnancy and breastfeeding (unless prescribed by a physician).

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🔹 Warnings and Precautions

• requires monitoring of laboratory parameters;

• should not be used without medical prescription;

• self-medication must be avoided.

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🔹 Adverse Reactions

Possible side effects may include:

• nausea, vomiting;

• changes in liver enzyme levels;

• hematologic abnormalities;

• other individual reactions.

If severe symptoms occur, seek medical attention immediately.

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🔹 Drug Interactions

Tretinoin may interact with other medicines. Patients should inform their physician about all drugs and supplements they are taking.

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🔹 Storage Conditions

• store below 25°C;

• protect from light and moisture;

• keep out of reach of children;

• do not use after expiration date.