Description

Gemdn 1000 (gemcitabine) is a prescription cytotoxic antineoplastic medication used in systemic oncology therapy for the treatment of various malignant tumors. It belongs to the class of antimetabolites (pyrimidine analogs) and is administered intravenously under strict medical supervision. The drug is widely used in modern chemotherapy protocols and is considered an effective component of combination anticancer regimens.

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Pharmacological Class

Antineoplastic agent — antimetabolite cytotoxic drug.

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Mechanism of Action

Gemcitabine enters tumor cells and is converted into active metabolites that integrate into DNA during synthesis. This process:

• inhibits DNA synthesis

• blocks cellular replication

• stops tumor cell division

• triggers programmed cell death (apoptosis)

As a result, tumor growth slows and cancer progression may be controlled.

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Indications

Gemdn 1000 is used in oncology for treatment of:

• pancreatic cancer

• non-small cell lung cancer (NSCLC)

• breast cancer

• other solid tumors as part of combination chemotherapy

The exact treatment regimen is determined individually by an oncologist.

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Dosage Form

• Lyophilized powder for solution for infusion

• Strength: 1000 mg

• Pack size: 1 vial

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Administration

The drug is administered intravenously after reconstitution. Dose, frequency, and duration of treatment depend on:

• tumor type and stage

• patient body surface area

• previous therapies

• overall patient condition

Treatment is usually given in cycles with rest periods between courses to allow recovery.

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Monitoring During Therapy

Regular medical monitoring is required, including:

• complete blood count

• liver and kidney function tests

• infection surveillance

• clinical condition assessment

This is essential due to possible bone marrow suppression and systemic toxicity.

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Possible Side Effects

Potential adverse reactions include:

• neutropenia, thrombocytopenia, anemia

• nausea and vomiting

• fatigue and weakness

• skin reactions

• increased risk of infections

Severe symptoms require immediate medical attention.

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Contraindications

• hypersensitivity to gemcitabine

• severe bone marrow suppression

• pregnancy and breastfeeding without medical supervision

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Drug Interactions

Patients should inform their physician about all medications they are taking, as gemcitabine may interact with other drugs, especially those affecting blood formation or immune function.

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Special Precautions

• Treatment must be supervised by an oncologist.

• Self-medication is not permitted.

• Dose adjustments may be required depending on laboratory results and tolerability.

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Pregnancy and Fertility

Gemcitabine may harm a developing fetus. Effective contraception is recommended during therapy.

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Prescription Status

Prescription only.

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Manufacturer

Biozenta Lifescience Pvt. Ltd.

Country of Manufacture

India