Description

Biotrexate® 2.5 mg is an antineoplastic medicinal product belonging to the class of antimetabolites (folic acid antagonists), widely used in oncology, rheumatology, and dermatology. The drug inhibits DNA synthesis and cell proliferation, particularly affecting rapidly dividing cells.

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Composition:

Active ingredient: Methotrexate – 2.5 mg per tablet
Excipients: lactose, starch, magnesium stearate, and others

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Pharmacotherapeutic Group:

• Antimetabolites
• Folic acid antagonists
• Antineoplastic and immunosuppressive agents

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Indications:

The drug is used for:

• oncological diseases (leukemia, lymphomas, sarcomas, breast cancer, lung cancer, etc.)
• severe forms of psoriasis
• rheumatoid arthritis
• psoriatic arthritis

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Mechanism of Action:

Methotrexate inhibits the enzyme dihydrofolate reductase, disrupting DNA and RNA synthesis and suppressing cell division. It also has immunosuppressive and anti-inflammatory effects.

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Dosage and Administration:

The drug must be used only under medical supervision.
For rheumatological and dermatological conditions, it is usually taken once weekly (very important!).

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Dosage Form:

Tablets 2.5 mg
Package: 100 tablets (10 blisters × 10 tablets)

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Manufacturer:

Zydus Lifesciences Limited, India

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Contraindications:

• pregnancy and breastfeeding
• severe liver or kidney impairment
• blood disorders
• active infections

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Side Effects:

• nausea, vomiting
• stomatitis
• decreased blood cell count
• elevated liver enzymes
• hair loss

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Storage Conditions:

Store at temperatures below 25°C, protected from light.

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⚠️ Important:

The drug has high toxicity and may cause serious adverse reactions.
👉 Do not use without a doctor’s prescription.