Pazokast-400 is a prescription oncology medicinal product based on pazopanib, which belongs to the class of targeted tyrosine kinase inhibitors. The medicine acts on key enzymes involved in tumor cell growth and the formation of the tumor vascular network (angiogenesis), thereby slowing tumor progression.

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🧠 Mechanism of Action

Pazopanib selectively blocks the activity of several tyrosine kinase receptors, including:

• VEGFR-1, VEGFR-2, VEGFR-3 (vascular endothelial growth factor receptors),

• PDGFR-α and PDGFR-β (platelet-derived growth factor receptors),

• c-KIT (tyrosine kinase receptor).

This combination of effects:

• inhibits angiogenesis (formation of new blood vessels),

• reduces blood supply to tumor tissue,

• slows the growth and spread of cancer cells.

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📍 Indications for Use

Pazokast-400 is used only upon recommendation of an oncologist as part of antitumor therapy in adult patients, particularly for:

Main indications:
✔ Renal cell carcinoma (RCC) — as monotherapy or combination therapy
✔ Soft tissue sarcomas (STS) — after prior treatment

(The regimen and treatment schedule are determined individually by a physician according to clinical protocols.)

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📊 Dosage and Administration

• Tablets are taken orally, whole, without chewing or crushing.

• Usually administered on an empty stomach — at least 1 hour before a meal or 2 hours after.

• The dose, regimen, and duration of treatment are determined individually by a physician depending on the patient’s condition, response to therapy, and comorbidities.

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🚫 Contraindications

Pazokast-400 should not be used in cases of:

• hypersensitivity to components,

• severe hepatic impairment,

• pregnancy and breastfeeding,

• certain cardiovascular diseases (as determined by a physician).

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⚠️ Precautions

During treatment the following may occur:

• impaired liver function,

• changes in blood and urine laboratory tests,

• arterial hypertension,

• risk of bleeding or infections,

• individual reactions.

Regular medical monitoring (laboratory tests, blood pressure, liver function) is mandatory.

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💊 Adverse Reactions

Possible (not in all patients):

• increased blood pressure,

• diarrhea, nausea,

• fatigue, weakness,

• hair color changes,

• liver function disorders,

• changes in blood parameters.

If severe symptoms occur, consult a physician.

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🍽 Drug Interactions

Pazopanib may interact with other medicines, especially:

• antihypertensive agents,

• drugs affecting heart rhythm,

• medicines metabolized in the liver (CYP3A4).

Before starting treatment, inform your doctor about all medications you are taking.

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🧪 Monitoring During Treatment

The physician may recommend:

• clinical blood tests,

• liver function tests,

• electrocardiogram,

• blood pressure monitoring.

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📦 Storage Conditions

Store in a dry place protected from light at a temperature up to 25°C, out of reach of children. Do not freeze.

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📋 General Information

• Brand name: Pazokast-400

• Active substance: Pazopanib hydrochloride 400 mg

• Pharmaceutical form: film-coated tablets

• Pack size: 30 tablets

• Manufacturer: Aprazer Healthcare Pvt. Ltd. (India)

• Category: targeted antitumor therapy (tyrosine kinase inhibitor)

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📌 Important

⚠ Prescription-only medicine.
⚠ Self-treatment with antitumor drugs is dangerous and contraindicated.
⚠ The entire course of treatment must be carried out under the supervision of an oncologist.