Description

Temozolomide 140 mg is a prescription anticancer medicinal product belonging to the class of alkylating agents (cytotoxic chemotherapy drugs). It is widely used in oncology for the treatment of malignant tumors, particularly tumors of the central nervous system. The drug is capable of crossing the blood–brain barrier, making it especially effective in brain tumor therapy.

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Pharmacological Class

Alkylating antineoplastic agent (cytostatic).

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Mechanism of Action

After oral administration, temozolomide is rapidly converted in the body into its active metabolite, which damages the DNA of tumor cells. This disrupts DNA replication and cell division, ultimately leading to inhibition of tumor growth and cancer cell death. Its ability to penetrate brain tissue makes it particularly effective for primary and recurrent brain tumors.

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Indications

Temozolomide is indicated for the treatment of:

• Newly diagnosed glioblastoma (in combination with radiotherapy, followed by maintenance therapy)

• Recurrent or progressive glioblastoma

• Anaplastic astrocytoma

• Other malignant brain tumors as determined by an oncologist

It may be used as monotherapy or as part of combination therapy.

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Dosage Form

Capsules 140 mg
Pack size: 5 capsules

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Dosage and Administration

Temozolomide is administered orally according to a treatment schedule prescribed by an oncologist. The dose and duration depend on:

• Type and stage of tumor

• Patient’s body surface area

• Previous treatments

• Overall clinical condition

Treatment is usually given in cycles, consisting of dosing periods followed by rest periods to allow recovery.

Capsules should be swallowed whole with water, preferably on an empty stomach or as directed by a healthcare professional.

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Monitoring During Therapy

Regular medical supervision is essential. Monitoring typically includes:

• Complete blood count (CBC)

• Liver and kidney function tests

• Assessment for signs of infection

• Evaluation of overall patient condition

Bone marrow suppression is a known risk and requires careful observation.

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Possible Side Effects

Common adverse reactions may include:

• Decreased white blood cells (neutropenia), platelets (thrombocytopenia), or red blood cells (anemia)

• Nausea and vomiting

• Fatigue and weakness

• Headache

• Increased risk of infections

Serious adverse reactions require immediate medical attention.

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Contraindications

• Hypersensitivity to temozolomide or similar compounds

• Severe bone marrow suppression

• Pregnancy and breastfeeding without medical supervision

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Drug Interactions

Patients should inform their healthcare provider about all medications being taken, as temozolomide may interact with other drugs, particularly those affecting bone marrow or immune function.

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Pregnancy and Fertility

Temozolomide may cause harm to a developing fetus. Effective contraception is recommended during treatment and for a period after therapy as advised by a physician.

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Storage and Handling

Store as directed by the manufacturer. Keep out of reach of children. Handle capsules carefully and do not open or crush them.

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Prescription Status

Prescription only. Treatment must be initiated and supervised by a qualified oncologist.

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Manufacturer

Biozenta Lifescience Pvt. Ltd.

Country of Manufacture

India