Description

Famvila-800 (Sevelamer Carbonate) Tablets 800 mg №50 is a modern phosphate-binding medication used for the management of hyperphosphatemia in patients with chronic kidney disease (CKD), including those undergoing hemodialysis or peritoneal dialysis.

The active substance, sevelamer carbonate, is a non-absorbed polymer that does not contain calcium or metals. It acts locally within the gastrointestinal tract by binding phosphate ions derived from food, forming insoluble complexes that are eliminated from the body via the intestines. This mechanism effectively reduces serum phosphorus levels without systemic absorption.

Controlling phosphorus levels is essential in patients with CKD, as elevated phosphate can lead to serious complications such as vascular calcification, bone disorders, and increased cardiovascular risk.

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⚠️ Why it is important:

As kidney function declines, the body loses its ability to excrete excess phosphorus, leading to accumulation. Elevated phosphate levels are associated with:

• vascular calcification
• cardiovascular complications
• bone metabolism disorders
• increased mortality in dialysis patients

Therefore, maintaining proper phosphate balance is a critical component of CKD management.

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⚙️ Mechanism of Action:

Sevelamer carbonate acts as an anion-exchange resin that:

• binds phosphate ions in the gastrointestinal tract
• reduces their bioavailability
• promotes elimination via feces

The drug is not absorbed or metabolized, minimizing systemic side effects.

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💊 Additional Therapeutic Effects:

In addition to phosphate control, sevelamer may:

• reduce total cholesterol and LDL levels
• decrease the risk of vascular calcification
• improve metabolic profile in CKD patients

This makes it particularly beneficial for patients with elevated cardiovascular risk.

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📦 Product Information:

• Brand name: Famvila-800
• Active ingredient: Sevelamer Carbonate
• Dosage: 800 mg
• Dosage form: Tablets
• Pack size: 50 tablets (5 × 10)
• Country of origin: India
• Manufacturer: Johnlee Pharmaceuticals Pvt. Ltd.

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📌 Indications:

• Hyperphosphatemia
• Chronic kidney disease (CKD)
• Patients on hemodialysis
• Patients on peritoneal dialysis

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📊 Efficacy:

Clinical data show that sevelamer:

• significantly lowers serum phosphorus levels
• helps achieve target phosphate levels
• is well tolerated for long-term use

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📌 Dosage and Administration:

Taken orally with meals, as it binds dietary phosphate.

Dosage should be individualized by a healthcare professional based on serum phosphorus levels.

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❗ Advantages:

• calcium-free (reduces risk of hypercalcemia)
• not systemically absorbed
• supports cardiovascular risk reduction
• may improve lipid profile
• suitable for long-term therapy

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❗ Warnings:

• use only as prescribed by a physician
• gastrointestinal side effects may occur (nausea, constipation)
• monitor phosphorus, calcium, and PTH levels
• consult a healthcare professional before use

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🧊 Storage Conditions:

Store in a dry place, protected from light, at temperatures up to +25°C.
Keep out of reach of children.