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Resmetirom 80 mg, 30 Tablets

170,00

 


Resmetirom 80 mg, 30 Tablets

Selective thyroid hormone receptor beta (THR-β) agonist indicated for the treatment of adults with non-cirrhotic MASH/NASH and liver fibrosis stages F2–F3. Resmetirom helps reduce liver fat accumulation, improves lipid metabolism, and may contribute to reducing inflammation and fibrosis progression.

Each pack contains 30 tablets of 80 mg. Intended for once-daily administration as prescribed by a healthcare professional, alongside diet and regular physical activity.

 

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Description

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Resmetirom 80 mg

30 tablets

A selective thyroid hormone receptor beta agonist, THR-β, indicated for the treatment of adult patients with noncirrhotic metabolic dysfunction-associated steatohepatitis and stage F2–F3 liver fibrosis.

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Dosage form

Tablets

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Strength

80 mg

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Pack size

30 tablets

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One pack provides

30 days*

*When prescribed as one tablet once daily.

What is Resmetirom?

Resmetirom is a medicinal product used for the treatment of metabolic dysfunction-associated steatohepatitis,
MASH, previously known as nonalcoholic steatohepatitis,
NASH.

The medicine belongs to a class of selective thyroid hormone receptor beta agonists,
THR-β. These receptors are found predominantly in the liver and are involved in the regulation of lipid metabolism.

Activation of THR-β helps increase fatty acid metabolism, reduce fat accumulation in the liver, and improve processes associated with inflammation and fibrosis of liver tissue.

How does Resmetirom work?

Mechanism Potential therapeutic effect
THR-β activation Activates thyroid hormone receptor beta primarily in liver cells.
Lipid metabolism Enhances the breakdown and oxidation of fatty acids.
Liver fat Helps reduce excessive fat accumulation in liver tissue.
Inflammation Reduction of liver fat may help decrease inflammatory activity.
Fibrosis Treatment may help improve fibrosis without worsening MASH activity.

Indications for use

Resmetirom is used together with diet and physical activity for the treatment of:

Adult patients with noncirrhotic MASH/NASH

The condition must be accompanied by moderate to advanced liver fibrosis corresponding to stages
F2–F3.

The decision to start treatment is made by a physician based on the clinical presentation, laboratory findings, and assessment of liver condition.


Dosage and administration

Patient body weight Recommended daily dose Pack suitability
Less than 100 kg 80 mg once daily Resmetirom 80 mg, 30 tablets
100 kg or more Usually 100 mg once daily A different strength is required as prescribed by a physician

Important information

Resmetirom is not a substitute for diet, weight management, or physical activity. It is used as part of a comprehensive treatment plan under medical supervision.

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What should I do if I miss a dose?

Take the missed dose as soon as you remember.

If it is almost time for your next dose, skip the missed dose and continue treatment according to your usual schedule.

Do not take a double dose to make up for a missed tablet.

Possible adverse reactions

Category Possible manifestations
Most common reactions Diarrhea, nausea, itching, vomiting, constipation, abdominal pain and dizziness.
Liver function abnormalities Elevated liver enzymes may occur. Rare cases of drug-induced liver injury have been reported.
Gallbladder disorders Gallstones, cholecystitis and other biliary complications may occur.

Seek immediate medical attention

Stop taking the medicine and seek urgent medical attention if any of the following occur:

  • yellowing of the skin or eyes;
  • dark urine;
  • severe weakness or unusual fatigue;
  • persistent nausea or vomiting;
  • severe pain in the upper right abdomen;
  • fever or chills;
  • rash, swelling of the face or lips, or difficulty breathing.

Contraindications and precautions

Condition or category Recommendation
Decompensated liver cirrhosis Use should be avoided.
Moderate or severe hepatic impairment Treatment should not be initiated without a physician’s decision.
Compensated cirrhosis Safety and efficacy have not been adequately established.
Patients under 18 years of age Safety and efficacy in pediatric patients have not been established.
Gallbladder disease Medical supervision and monitoring are recommended.
Pregnancy and breastfeeding Treatment should only be considered after a physician evaluates the benefits and risks.

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Drug Interactions

Inform your healthcare provider about all medicines you are taking before starting treatment.

Drug or Drug Class Recommendation
Strong CYP2C8 inhibitors (e.g. gemfibrozil) Concomitant use is not recommended due to significant increase in Resmetirom exposure.
OATP1B1/OATP1B3 inhibitors (e.g. cyclosporine) Co-administration is generally not recommended.
Statins Dose adjustment and clinical monitoring may be required due to increased statin exposure.
CYP2C8 substrate medicines Increased plasma concentrations may occur. Medical supervision is recommended.

Storage Conditions

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Temperature

Store below 30°C

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Keep out of reach

Keep out of reach of children

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Packaging

Store in the original package

Medical Disclaimer

This information is intended for educational purposes only and should not replace consultation with a qualified healthcare professional. Do not use this information for self-diagnosis, self-treatment, dose adjustment, or discontinuation of prescribed therapy without medical advice.

Pharmaceutical Classification

Therapeutic area: Hepatology
Pharmacological class: Selective thyroid hormone receptor beta (THR-β) agonist
Category: Pharmaceutical products / Liver disease treatment

 

Frequently Asked Questions about Resmetirom 80 mg

Answers to the most common questions regarding treatment with Resmetirom

What condition is Resmetirom used to treat?
Resmetirom is used together with diet and physical activity for the treatment of adults with non-cirrhotic MASH (metabolic dysfunction-associated steatohepatitis), previously known as NASH, and liver fibrosis stages F2–F3.

How is MASH different from simple fatty liver disease?
In MASH, fat accumulation in the liver is accompanied by inflammation and liver cell damage. Over time this may lead to fibrosis, cirrhosis and other serious complications.

Who is the 80 mg dosage intended for?
The standard 80 mg once-daily dose is intended for adult patients weighing less than 100 kg. Final dosing should always be determined by the treating physician.

How long does a pack of 30 tablets last?
If prescribed as one 80 mg tablet once daily, a pack of 30 tablets provides a 30-day treatment course.

Should Resmetirom be taken with food?
Resmetirom may be taken with or without food. It is recommended to take the medicine at approximately the same time each day.

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